Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evolution of Plasmid-Mediated Antibiotic Resistance in the Clinical Context.

Trends in microbiology - 1 Dec 2018

San Millan Alvaro

Abstract excerpt

Antibiotic-resistant infections are an urgent problem in clinical settings because they sharply increase mortality risk in critically ill patients. The horizontal spread of antibiotic resistance genes among bacteria is driven by bacterial plasmids, promoting the evolution of resistance. Crucially, particular associations exist between resistance plasmids and bacterial clones that become especially successful in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptation, Physiological
Share to Anti-Bacterial Agents
Share to Bacteria

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drug Resistance, Microbial

Share to Evolution, Molecular

Share to Gastrointestinal Microbiome

Share to Gene Transfer, Horizontal

Share to Plasmids

Source

Identifiers

PMID: 30049587
DOI: 10.1016/j.tim.2018.06.007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evolution of Plasmid-Mediated Antibiotic Resistance in the Clinical Context.PMID 30049587Read ↗

Host-specific plasmid evolution explains the variable spread of clinical antibiotic-resistance plasmidsSemantic proximity Read ↗

Within-patient evolution of plasmid-mediated antimicrobial resistanceSemantic proximity Read ↗

Plasmid-encoded insertion sequences promote rapid adaptation in clinical enterobacteriaSemantic proximity Read ↗

Colonization of gut microbiota by plasmid-carrying bacteria is facilitated by evolutionary adaptation to antibiotic treatmentSemantic proximity Read ↗

Evolutionary Responses to Acquiring a Multidrug Resistance Plasmid Are Dominated by Metabolic Functions across Diverse Escherichia coli LineagesSemantic proximity Read ↗

Microbial Evolution: Towards Resolving the Plasmid Paradox.Semantic proximity Read ↗

Evolutionary mechanisms that determine which bacterial genes are carried on plasmidsSemantic proximity Read ↗

Compensatory mutations improve general permissiveness to antibiotic resistance plasmids.Semantic proximity Read ↗

Antibiotic resistance begets more resistance: chromosomal resistance mutations mitigate fitness costs conferred by multi-resistant clinical plasmids.Semantic proximity Read ↗

Beyond horizontal gene transfer: the role of plasmids in bacterial evolution.Semantic proximity Read ↗

Survival and Evolution of a Large Multidrug Resistance Plasmid in New Clinical Bacterial HostsSemantic proximity Read ↗

Evolution and maintenance of a large multidrug-resistant plasmid in a Salmonella enterica Typhimurium host under differing antibiotic selection pressuresSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.