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Article

Chance Favors the Prepared Genomes: Horizontal Transfer Shapes the Emergence of Antibiotic Resistance Mutations in Core Genes.

Molecular biology and evolution - 4 Oct 2023

Coluzzi Charles, Guillemet Martin, Mazzamurro Fanny, Touchon Marie, Godfroid Maxime, Achaz Guillaume, Glaser Philippe, Rocha Eduardo P C

Abstract excerpt

Bacterial lineages acquire novel traits at diverse rates in part because the genetic background impacts the successful acquisition of novel genes by horizontal transfer. Yet, how horizontal transfer affects the subsequent evolution of core genes remains poorly understood. Here, we studied the evolution of resistance to quinolones in Escherichia coli accounting for population structure. We found 60 groups of genes...

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Share to Anti-Bacterial Agents
Share to Drug Resistance, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Multiple, Bacterial

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Share to Gene Transfer, Horizontal

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Share to Plasmids

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Source

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Identifiers

PMID: 37788575
DOI: 10.1093/molbev/msad217
PMCID: PMC10575684

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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