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Article

RNAi-mediated knockdown of IKK1 in transgenic mice using a transgenic construct containing the human H1 promoter.

TheScientificWorldJournal - 1 Jan 2014

Moreno-Maldonado Rodolfo, Murillas Rodolfo, Navarro Manuel, Page Angustias, Suarez-Cabrera Cristian, Alameda Josefa P, Bravo Ana, Casanova M Llanos, Ramirez Angel

Abstract excerpt

Inhibition of gene expression through siRNAs is a tool increasingly used for the study of gene function in model systems, including transgenic mice. To achieve perdurable effects, the stable expression of siRNAs by an integrated transgenic construct is necessary. For transgenic siRNA expression, promoters transcribed by either RNApol II or III (such as U6 or H1 promoters) can be used. Relatively large amounts of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24523631
DOI: 10.1155/2014/193803
PMCID: PMC3913291

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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