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Article

Silencing of the Pink1 gene expression by conditional RNAi does not induce dopaminergic neuron death in mice.

International journal of biological sciences - 5 Mar 2007

Zhou Hongxia, Falkenburger Björn H, Schulz Jörg B, Tieu Kim, Xu Zuoshang, Xia Xu Gang

Abstract excerpt

Transgenic RNAi, an alternative to the gene knockout approach, can induce hypomorphic phenotypes that resemble those of the gene knockout in mice. Conditional transgenic RNAi is an attractive choice of method for reverse genetics in vivo because it can achieve temporal and spatial silencing of targeted genes. Pol III promoters such as U6 are widely used to drive the expression of RNAi transgenes in animals....

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Source

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Identifiers

PMID: 17389931
DOI: 10.7150/ijbs.3.242
PMCID: PMC1820878

Genes

PINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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