Selective pharmacological inhibition of DDR1 prevents experimentally-induced glomerulonephritis in prevention and therapeutic regime.

doi:10.1186/s12967-018-1524-5

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Article

Selective pharmacological inhibition of DDR1 prevents experimentally-induced glomerulonephritis in prevention and therapeutic regime.

Journal of translational medicine - 1 Jun 2018

Moll Solange, Yasui Yukari, Abed Ahmed, Murata Takeshi, Shimada Hideaki, Maeda Akira, Fukushima Naoshi, Kanamori Masakazu, Uhles Sabine, Badi Laura, Cagarelli Thomas, Formentini Ivan, Drawnel Faye, Georges Guy, Bergauer Tobias, Gasser Rodolfo, Bonfil R Daniel, Fridman Rafael, Richter Hans, Funk Juergen, Moeller Marcus J, Chatziantoniou Christos, Prunotto Marco

Abstract excerpt

BACKGROUND: Discoidin domain receptor 1 (DDR1) is a collagen-activated receptor tyrosine kinase extensively implicated in diseases such as cancer, atherosclerosis and fibrosis. Multiple preclinical studies, performed using either a gene deletion or a gene silencing approaches, have shown this receptor being a major driver target of fibrosis and glomerulosclerosis. METHODS: The present study investigated the role...

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PMID: 29859097
DOI: 10.1186/s12967-018-1524-5
PMCID: PMC5984769

Genes

DDR1
NTS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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