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Article

Mitoflash frequency in early adulthood predicts lifespan in Caenorhabditis elegans.

Nature - 3 Apr 2014

Shen En-Zhi, Song Chun-Qing, Lin Yuan, Zhang Wen-Hong, Su Pei-Fang, Liu Wen-Yuan, Zhang Pan, Xu Jiejia, Lin Na, Zhan Cheng, Wang Xianhua, Shyr Yu, Cheng Heping, Dong Meng-Qiu

Abstract excerpt

It has been theorized for decades that mitochondria act as the biological clock of ageing, but the evidence is incomplete. Here we show a strong coupling between mitochondrial function and ageing by in vivo visualization of the mitochondrial flash (mitoflash), a frequency-coded optical readout reflecting free-radical production and energy metabolism at the single-mitochondrion level. Mitoflash activity in...

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PMID: 24522532
DOI: 10.1038/nature13012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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