Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ABCB1 polymorphism and gender affect the pharmacokinetics of amlodipine in Chinese patients with essential hypertension: a population analysis.

Drug metabolism and pharmacokinetics - 1 Jan 2014

Zuo Xiao-cong, Zhang Wen-li, Yuan Hong, Barrett Jeffrey S, Hua Ye, Huang Zhi-jun, Zhou Hong-hao, Pei Qi, Guo Cheng-xian, Wang Jiang-lin, Yang Guo-ping

Abstract excerpt

The effects of genetic polymorphisms of ABCB1 C3435T, POR*28, CYP3A4*1G and CYP3A5*3 variants and gender relating to metabolism on the exposure and response of amlodipine in Chinese hypertensive patients were determined. Population pharmacokinetic analyses were performed on data which were collected prospectively from 60 Chinese patients with mild to moderate essential hypertension [age range 40-74 years, males...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asian People
Share to ATP Binding Cassette Transporter, Subfamily B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Blood Pressure

Share to Cytochrome P-450 CYP3A

Share to Essential Hypertension

Share to Hypertension

Share to NADPH-Ferrihemoprotein Reductase

Share to Sex Characteristics

Source

Identifiers

PMID: 24522199
DOI: 10.2133/dmpk.dmpk-13-rg-127

Genes

ABCB1
POR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ABCB1 polymorphism and gender affect the pharmacokinetics of amlodipine in Chinese patients with essential hypertension: a population analysis.PMID 24522199Read ↗

Effect of CYP3A4*1G, CYP3A5*3, POR*28, and ABCB1 C3435T on the pharmacokinetics of nifedipine in healthy Chinese volunteers.Semantic proximity Read ↗

Influence of ABCB1 gene polymorphisms on the pharmacokinetics of verapamil among healthy Chinese Han ethnic subjects.Semantic proximity Read ↗

Gender-Specific Effect of CYP2C8*3 on the Risk of Essential Hypertension in Bulgarian PatientsSemantic proximity Read ↗

Do MDR1 and SLCO1B1 polymorphisms influence the therapeutic response to atorvastatin? A study on a cohort of Egyptian patients with hypercholesterolemia.Semantic proximity Read ↗

Effect of CYP3A5*3 genotype on the pharmacokinetics and pharmacodynamics of amlodipine in healthy Korean subjects.Semantic proximity Read ↗

Effects of cytochrome P450 oxidoreductase genotypes on the pharmacokinetics of amlodipine in healthy Korean subjects.Semantic proximity Read ↗

CYP3A5 polymorphism, amlodipine and hypertension.Semantic proximity Read ↗

Effects of two functionally important SLCO1B1 gene polymorphisms on pharmacokinetics of atorvastatin.Semantic proximity Read ↗

ABCB1 c.2677G>T/c.3435C>T diplotype increases the early-phase oral absorption of losartan.Semantic proximity Read ↗

Effects of genetic variants in UGT1A1, SLCO1B3, ABCB1, ABCC2, ABCG2, ORM1 on PK/PD of telmisartan in Chinese patients with mild to moderate essential hypertension .Semantic proximity Read ↗

The effect of gender and ABCB1 gene polymorphism on the pharmacokinetics of azithromycin in healthy male and female Pakistani subjects.Semantic proximity Read ↗

CYP3A5 and ABCB1 genes and hypertension.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.