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Article

The effect of gender and ABCB1 gene polymorphism on the pharmacokinetics of azithromycin in healthy male and female Pakistani subjects.

Canadian journal of physiology and pharmacology - 1 Aug 2020

Nazir Shabnam, Adnan Kashif, Gul Rukhsana, Ali Gowhar, Saleha Shamim, Khan Amjad

Abstract excerpt

In the current study, the possible outcome of gender difference and genotypic polymorphism of the ABCB1 gene encoding P-glycoprotein on the pharmacokinetics of azithromycin has been evaluated. An open-label, comparative pharmacokinetic study was done in healthy Pakistani volunteers (females (n = 8) and males (n = 8)). They were administered a single 500 mg oral dose of azithromycin. Blood samples (≈5 mL) were...

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Identifiers

PMID: 32125889
DOI: 10.1139/cjpp-2019-0569

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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