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Effect of CYP3A5*3 genotype on the pharmacokinetics and pharmacodynamics of amlodipine in healthy Korean subjects.

Clinical pharmacology and therapeutics - 1 Dec 2006

Kim Kyoung-Ah, Park Pil-Whan, Lee Ock-Je, Choi Sang-Hyun, Min Bon Hong, Shin Kyung-Ho, Chun Boe-Gwun, Shin Jae-Gook, Park Ji-Young

Abstract excerpt

BACKGROUND AND OBJECTIVE: 1,4-Dihydropyridine calcium channel blockers, including amlodipine, are mainly metabolized by cytochrome P450 (CYP) 3A. We investigated the effect of CYP3A5*3 genotype on the pharmacokinetics and pharmacodynamics of amlodipine in healthy Korean male subjects. METHODS: Forty healthy male participants were enrolled and genotyped for the CYP3A5*3 gene. Each subject ingested a 5-mg dose of...

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PMID: 17178265
DOI: 10.1016/j.clpt.2006.09.009

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