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Article

Naïve subset develops the most important alloreactive response among human CD4+ T lymphocytes in human leukocyte antigen-identical related setting.

European journal of haematology - 1 Jun 2014

Chérel Mathilde, Choufi Bachra, Trauet Jacques, Cracco Pascale, Dessaint Jean-Paul, Yakoub-Agha Ibrahim, Labalette Myriam

Abstract excerpt

In longitudinal clinical studies, receiving a high percentage of allogeneic donor-derived CD4(+) CCR7(+) T cells, which include naïve and central memory subsets have been correlated with increased incidence and severity of acute GVHD. Whether naïve and central memory CD4(+) T-cell subsets contribute more or equally to alloimmune responses are still unclear in human. The aim of this study was to investigate in...

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Source

Identifiers

PMID: 24520815
DOI: 10.1111/ejh.12283

Genes

CCR7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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