Article
Characterization of a subset of antigen-specific human central memory CD4+ T lymphocytes producing effector cytokines.
European journal of immunology - 1 Jan 2008
Stubbe Muriel, Vanderheyde Nathalie, Pircher Hanspeter, Goldman Michel, Marchant Arnaud
Abstract excerpt
CCR7(+ )central memory (T(CM)) CD4(+) T cells play a central role in long-term immunological memory. Recent reports indicate that a proportion of CD4(+) T(CM) is able to produce effector cytokines. The phenotype and the role of this subset remain unknown. We characterized cytokine-producing human CD4(+) T(CM) specific for cleared protein and persistent viral Ag. Our results demonstrate that the type of Ag...
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