Article
A genome-wide association study of intra-ocular pressure suggests a novel association in the gene FAM125B in the TwinsUK cohort.
Human molecular genetics - 15 Jun 2014
Nag Abhishek, Venturini Cristina, Small Kerrin S, Young Terri L, Viswanathan Ananth C, Mackey David A, Hysi Pirro G, Hammond Christopher
Abstract excerpt
Glaucoma is a major cause of blindness in the world. To date, common genetic variants associated with glaucoma only explain a small proportion of its heritability. We performed a genome-wide association study of intra-ocular pressure (IOP), an underlying endophenotype for glaucoma. The discovery phase of the study was carried out in the TwinsUK cohort (N = 2774) analyzing association between IOP and single...
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