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Article

Exome array analysis identifies CAV1/CAV2 as a susceptibility locus for intraocular pressure.

Investigative ophthalmology & visual science - 18 Dec 2014

Chen Fei, Klein Alison P, Klein Barbara E K, Lee Kristine E, Truitt Barbara, Klein Ronald, Iyengar Sudha K, Duggal Priya

Abstract excerpt

PURPOSE: Intraocular pressure (IOP) is an important clinical parameter in the evaluation of ocular health. Elevated IOP is a major risk factor for primary open-angle glaucoma (POAG). The goal of this study was to identify rare and less common variants that influence IOP. METHODS: We performed an exome array analysis in a subset of 1660 individuals from a population-based cohort, the Beaver Dam Eye Study....

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Source

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Identifiers

PMID: 25525164
DOI: 10.1167/iovs.14-15204
PMCID: PMC4303040

Genes

CAV1
CAV2
FAR2
FREM3
GAS7
GGA3
HAP1
MTBP
PHF12
PKDREJ

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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