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Article

The Relationship between NALP3 and Autoinflammatory Syndromes

13 May 2016

Abstract excerpt

The nucleotide-binding domain, leucine-rich repeat/pyrin domain-containing-3 (NALP3) inflammasome, which is required for synthesis of interleukin-1β, has been implicated in the pathogenesis of several autoinflammatory syndromes. This review of the literature summarizes the interconnectedness of NALP3 inflammasome with some of these disorders. Familial Mediterranean fever results from a mutation in the...

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PMID: 27187378
DOI: 10.3390/ijms17050725

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