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Article

The NLRP3 and Pyrin Inflammasomes: Implications in the Pathophysiology of Autoinflammatory Diseases

27 Jan 2017

Abstract excerpt

Inflammasomes are multiprotein complexes that critically control different aspects of innate and adaptive immunity. Among them we could highlight the release of pro-inflammatory cytokines that induces and maintains the inflammatory response. Usually, inflammasomes results from oligomerization of a nucleotide-binding domain-like receptor (NLR) after sensing different pathogenic or endogenous sterile dangerous...

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PMID: 28191008
DOI: 10.3389/fimmu.2017.00043

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