Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Risk factors for dopaminergic neuron loss in human α‐synuclein transgenic mice

1 Feb 2004

Abstract excerpt

Genetic background, pesticide exposure, age, gender, diet and lifestyle are implicated risk factors in Parkinson's disease. We demonstrate dopamine neuron loss and other features of Parkinsonism based on the interaction of several of these human risk factors in transgenic mice expressing human alpha-synuclein. Mice expressing different forms of human alpha-synuclein had progressive declines in locomotor activity...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Nerve injury and regeneration
Share to Nuclear Receptors and Signaling
Share to Parkinson's Disease Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15009131
DOI: 10.1111/j.0953-816x.2004.03139.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Risk factors for dopaminergic neuron loss in human α‐synuclein transgenic micePMID 15009131Read ↗

Transgenic Models of α‐Synuclein PathologySemantic proximity Read ↗

Neuronal Oxidative Stress Promotes α-Synuclein Aggregation In VivoSemantic proximity Read ↗

Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson’s diseaseSemantic proximity Read ↗

α-Synuclein in Parkinson's Disease: Pathogenic Function and Translation into Animal ModelsSemantic proximity Read ↗

Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice.Semantic proximity Read ↗

Differential neuropathological alterations in transgenic mice expressing α‐synuclein from the platelet‐derived growth factor and Thy‐1 promotersSemantic proximity Read ↗

Alpha-synuclein and transgenic mouse modelsSemantic proximity Read ↗

The role of alpha-synuclein in Parkinson's disease: insights from animal models.Semantic proximity Read ↗

Mouse models of alpha-synucleinopathy and Lewy pathology. Alpha-synuclein expression in transgenic mice.Semantic proximity Read ↗

α-Synuclein Transgenic Mice Reveal Compensatory Increases in Parkinson's Disease-Associated Proteins DJ-1 and Parkin and Have Enhanced α-Synuclein and PINK1 Levels After Rotenone TreatmentSemantic proximity Read ↗

Dopaminergic Loss and Inclusion Body Formation in α-Synuclein Mice: Implications for Neurodegenerative DisordersSemantic proximity Read ↗

Modeling Parkinson's disease‐related symptoms in alpha‐synuclein overexpressing miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.