Article
HCV-1b intra-subtype variability: Impact on genetic barrier to protease inhibitors.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Apr 2014
Ferraro Donatella, Urone Noemi, Di Marco Vito, Craxì Antonio
Abstract excerpt
Due to error-prone RNA polymerase and the lack of proofreading mechanisms, to the spread worldwide and probable long-term presence in human population, HCV showed a high degree of inter- and intra-subtype genetic variability. Protease inhibitors (PIs), a new class of drugs, have been designed specifically on the HCV genotype 1 NS3 protease three-dimensional structure. The viral genetic barrier limits the efficacy...
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