Article
HCV genotypes are differently prone to the development of resistance to linear and macrocyclic protease inhibitors.
PloS one - 1 Jan 2012
Cento Valeria, Mirabelli Carmen, Salpini Romina, Dimonte Salvatore, Artese Anna, Costa Giosuè, Mercurio Fabio, Svicher Valentina, Parrotta Lucia, Bertoli Ada, Ciotti Marco, Di Paolo Daniele, Sarrecchia Cesare, Andreoni Massimo, Alcaro Stefano, Angelico Mario, Perno Carlo Federico, Ceccherini-Silberstein Francesca
Abstract excerpt
BACKGROUND: Because of the extreme genetic variability of hepatitis C virus (HCV), we analyzed whether specific HCV-genotypes are differently prone to develop resistance to linear and macrocyclic protease-inhibitors (PIs). METHODS: The study includes 1568 NS3-protease sequences, isolated from PI-naive patients infected with HCV-genotypes 1a (N = 621), 1b (N = 474), 2 (N = 72), 3 (N = 268), 4 (N = 54) 5 (N = 6),...
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