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Article

Genetic Barrier to Direct Acting Antivirals in HCV Sequences Deposited in the European Databank.

PloS one - 1 Jan 2016

Kliemann Dimas Alexandre, Tovo Cristiane Valle, Gorini da Veiga Ana Beatriz, Machado André Luiz, West John

Abstract excerpt

BACKGROUND & AIMS: Development of resistance results from mutations in the viral genome, and the presence of selective drug pressure leads to the emergence of a resistant virus population. The aim of this study was to analyze the impact of genetic variability on the genetic barrier to drug resistance to DAAs. METHODS: The genetic barrier was quantified based on the number and type of nucleotide mutations required...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27504952
DOI: 10.1371/journal.pone.0159924
PMCID: PMC4978475

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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