Article
ZO-1 interactions with F-actin and occludin direct epithelial polarization and single lumen specification in 3D culture.
Journal of cell science - 1 Jan 2017
Odenwald Matthew A, Choi Wangsun, Buckley Aaron, Shashikanth Nitesh, Joseph Nora E, Wang Yitang, Warren Michael H, Buschmann Mary M, Pavlyuk Roman, Hildebrand Jeffrey, Margolis Ben, Fanning Alan S, Turner Jerrold R
Abstract excerpt
Epithelia within tubular organs form and expand lumens. Failure of these processes can result in serious developmental anomalies. Although tight junction assembly is crucial to epithelial polarization, the contribution of specific tight junction proteins to lumenogenesis is undefined. Here, we show that ZO-1 (also known as TJP1) is necessary for the formation of single lumens. Epithelia lacking this tight...
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