Article
Lamellar projections in the endolymphatic sac act as a relief valve to regulate inner ear pressure.
eLife - 19 Jun 2018
Swinburne Ian A, Mosaliganti Kishore R, Upadhyayula Srigokul, Liu Tsung-Li, Hildebrand David G C, Tsai Tony Y-C, Chen Anzhi, Al-Obeidi Ebaa, Fass Anna K, Malhotra Samir, Engert Florian, Lichtman Jeff W, Kirchhausen Tomas, Betzig Eric, Megason Sean G
Abstract excerpt
The inner ear is a fluid-filled closed-epithelial structure whose function requires maintenance of an internal hydrostatic pressure and fluid composition. The endolymphatic sac (ES) is a dead-end epithelial tube connected to the inner ear whose function is unclear. ES defects can cause distended ear tissue, a pathology often seen in hearing and balance disorders. Using live imaging of zebrafish larvae, we reveal...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.