Article
Sequential pulses of apical epithelial secretion and endocytosis drive airway maturation in Drosophila.
Developmental cell - 1 Aug 2007
Tsarouhas Vasilios, Senti Kirsten-André, Jayaram Satish Arcot, Tiklová Katarína, Hemphälä Johanna, Adler Jeremy, Samakovlis Christos
Abstract excerpt
The development of air-filled respiratory organs is crucial for survival at birth. We used a combination of live imaging and genetic analysis to dissect respiratory organ maturation in the embryonic Drosophila trachea. We found that tracheal tube maturation entails three precise epithelial transitions. Initially, a secretion burst deposits proteins into the lumen. Solid luminal material is then rapidly cleared...
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