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Article

Distinct genomic integration of MLV and SIV vectors in primate hematopoietic stem and progenitor cells.

PLoS biology - 1 Dec 2004

Hematti Peiman, Hong Bum-Kee, Ferguson Cole, Adler Rima, Hanawa Hideki, Sellers Stephanie, Holt Ingeborg E, Eckfeldt Craig E, Sharma Yugal, Schmidt Manfred, von Kalle Christof, Persons Derek A, Billings Eric M, Verfaillie Catherine M, Nienhuis Arthur W, Wolfsberg Tyra G, Dunbar Cynthia E, Calmels Boris

Abstract excerpt

Murine leukemia virus (MLV)-derived vectors are widely used for hematopoietic stem cell (HSC) gene transfer, but lentiviral vectors such as the simian immunodeficiency virus (SIV) may allow higher efficiency transfer and better expression. Recent studies in cell lines have challenged the notion t...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15550989
DOI: 10.1371/journal.pbio.0020423
PMCID: PMC529319

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15550989-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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