Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High-Definition Mapping of Retroviral Integration Sites Defines the Fate of Allogeneic T Cells After Donor Lymphocyte Infusion

22 Dec 2010

Abstract excerpt

The infusion of donor lymphocytes transduced with a retroviral vector expressing the HSV-TK suicide gene in patients undergoing hematopoietic stem cell transplantation for leukemia/lymphoma promotes immune reconstitution and prevents infections and graft-versus-host disease. Analysis of the clonal dynamics of genetically modified lymphocytes in vivo is of crucial importance to understand the potential genotoxic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to CRISPR and Genetic Engineering
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21203516
DOI: 10.1371/journal.pone.0015688

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High-Definition Mapping of Retroviral Integration Sites Defines the Fate of Allogeneic T Cells After Donor Lymphocyte InfusionPMID 21203516Read ↗

Genome-wide profiling of retroviral DNA integration and its effect on clinical pre-infusion CAR T-cell productsSemantic proximity Read ↗

Amplification, Next-generation Sequencing, and Genomic DNA Mapping of Retroviral Integration SitesSemantic proximity Read ↗

Amplification, Next-generation Sequencing, and Genomic DNA Mapping of Retroviral Integration SitesSemantic proximity Read ↗

LISA: A Comprehensive R Package for Lentiviral Integration Site Analysis in Gene Therapy Safety AssessmentSemantic proximity Read ↗

DNA bar coding and pyrosequencing to analyze adverse events in therapeutic gene transferSemantic proximity Read ↗

Sites of retroviral DNA integration: From basic research to clinical applicationsSemantic proximity Read ↗

Analysis of Lentiviral Vector Integration in HIV+ Study Subjects Receiving Autologous Infusions of Gene Modified CD4+ T CellsSemantic proximity Read ↗

An analytical pipeline for identifying and mapping the integration sites of HIV and other retrovirusesSemantic proximity Read ↗

Enhancers Are Major Targets for Murine Leukemia Virus Vector IntegrationSemantic proximity Read ↗

Identification of HIV integration sites in infected host genomic DNASemantic proximity Read ↗

Novel extragenic genomic safe harbors for precise therapeutic T cell engineeringSemantic proximity Read ↗

GENE-IS: Time-Efficient and Accurate Analysis of Viral Integration Events in Large-Scale Gene Therapy DataSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.