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Article

Ex vivo Ikkβ ablation rescues the immunopotency of mesenchymal stromal cells from diabetics with advanced atherosclerosis.

Cardiovascular research - 22 Feb 2021

Kizilay Mancini Ozge, Huynh David N, Menard Liliane, Shum-Tim Dominique, Ong Huy, Marleau Sylvie, Colmegna Ines, Servant Marc J

Abstract excerpt

AIMS: Diabetes is a conventional risk factor for atherosclerotic cardiovascular disease and myocardial infarction (MI) is the most common cause of death among these patients. Mesenchymal stromal cells (MSCs) in patients with type 2 diabetes mellitus (T2DM) and atherosclerosis have impaired ability to suppress activated T-cells (i.e. reduced immunopotency). This is mediated by an inflammatory shift in MSC-secreted...

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Identifiers

PMID: 32339220
DOI: 10.1093/cvr/cvaa118
PMCID: PMC7898947

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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