A mitochondrial target sequence polymorphism in manganese superoxide dismutase predicts inferior survival in breast cancer patients treated with cyclophosphamide.

doi:10.1158/1078-0432.CCR-09-0119

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Article

A mitochondrial target sequence polymorphism in manganese superoxide dismutase predicts inferior survival in breast cancer patients treated with cyclophosphamide.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jun 2009

Glynn Sharon A, Boersma Brenda J, Howe Tiffany M, Edvardsen Hege, Geisler Stephanie B, Goodman Julie E, Ridnour Lisa A, Lønning Per E, Børresen-Dale Anne-Lise, Naume Bjorn, Kristensen Vessela N, Chanock Stephen J, Wink David A, Ambs Stefan

Abstract excerpt

PURPOSE: Manganese superoxide dismutase protects against oxidative damage and modulates the efficacy of chemotherapeutic drugs. A functional single-nucleotide polymorphism in codon 16 of SOD2 (rs4880), which encodes manganese superoxide dismutase, results in a substitution of valine by alanine (V...

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PMID: 19509150
DOI: 10.1158/1078-0432.CCR-09-0119
PMCID: PMC2697269

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SOD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19509150-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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