Article
MnSOD rs4880 and XPD rs13181 polymorphisms predict the survival of breast cancer patients treated with adjuvant tamoxifen.
Acta oncologica (Stockholm, Sweden) - 1 Jun 2014
Tengström Maria, Mannermaa Arto, Kosma Veli-Matti, Soini Ylermi, Hirvonen Ari, Kataja Vesa
Abstract excerpt
UNLABELLED: The enzyme manganese superoxide dismutase (MnSOD) defends against oxidative stress caused by reactive oxygen species (ROS), whereas Xeroderma pigmentosum group D (XPD) protein is involved in DNA repair. Polymorphisms in these genes have previously been associated with the outcome of breast cancer. MATERIAL AND METHODS: Two gene polymorphisms, the MnSOD Val16Ala (rs4880A>G) and the XPD Lys751Gln...
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