Article
Single-nucleotide polymorphisms and the effectiveness of taxane-based chemotherapy in premenopausal breast cancer: a population-based cohort study in Denmark.
Breast cancer research and treatment - 1 Jul 2022
Hjorth Cathrine F, Damkier Per, Stage Tore B, Feddersen Søren, Hamilton-Dutoit Stephen, Rørth Mikael, Ejlertsen Bent, Lash Timothy L, Ahern Thomas P, Sørensen Henrik T, Cronin-Fenton Deirdre
Abstract excerpt
PURPOSE: Taxane-based chemotherapy is the primary treatment for premenopausal breast cancer. Although being inconsistent, research suggests that variant alleles alter pharmacokinetics through reduced function of OATP transporters (limiting hepatic uptake), CYP-450 enzymes (hampering drug metabolism), and ABC transporters (decreasing clearance). Reduced function of DNA repair enzymes may hamper effectiveness...
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