Article
Gene x Gene interaction between MnSOD and GPX-1 and breast cancer risk: a nested case-control study.
BMC cancer - 31 Aug 2006
Cox David G, Tamimi Rulla M, Hunter David J
Abstract excerpt
BACKGROUND: Germ-line mutations in genes such as BRCA1, BRCA2, and ATM can cause a substantial increase in risk of breast cancer. However, these mutations are rare in the general population, and account for little of the incidence of sporadic breast cancer in the general population. Therefore, research has been focused on examining associations between common polymorphisms and breast cancer risk. To date, few...
Topics
- Alleles
- Case-Control Studies
- Female
- Gene Expression Regulation, Neoplastic
- Genetic Predisposition to Disease
- Genotype
- Germ-Line Mutation
- Glutathione Peroxidase
- Humans
- Odds Ratio
- Phenotype
- Polymorphism, Genetic
- Risk
- Superoxide Dismutase
- Glutathione Peroxidase GPX1