Article
Re-sequencing expands our understanding of the phenotypic impact of variants at GWAS loci.
PLoS genetics - 1 Jan 2014
Service Susan K, Teslovich Tanya M, Fuchsberger Christian, Ramensky Vasily, Yajnik Pranav, Koboldt Daniel C, Larson David E, Zhang Qunyuan, Lin Ling, Welch Ryan, Ding Li, McLellan Michael D, O'Laughlin Michele, Fronick Catrina, Fulton Lucinda L, Magrini Vincent, Swift Amy, Elliott Paul, Jarvelin Marjo-Riitta, Kaakinen Marika, McCarthy Mark I, Peltonen Leena, Pouta Anneli, Bonnycastle Lori L, Collins Francis S, Narisu Narisu, Stringham Heather M, Tuomilehto Jaakko, Ripatti Samuli, Fulton Robert S, Sabatti Chiara, Wilson Richard K, Boehnke Michael, Freimer Nelson B
Abstract excerpt
Genome-wide association studies (GWAS) have identified >500 common variants associated with quantitative metabolic traits, but in aggregate such variants explain at most 20-30% of the heritable component of population variation in these traits. To further investigate the impact of genotypic variation on metabolic traits, we conducted re-sequencing studies in >6,000 members of a Finnish population cohort (The...
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