Article
Analysis with the exome array identifies multiple new independent variants in lipid loci.
Human molecular genetics - 15 Sept 2016
Kanoni Stavroula, Masca Nicholas G D, Stirrups Kathleen E, Varga Tibor V, Warren Helen R, Scott Robert A, Southam Lorraine, Zhang Weihua, Yaghootkar Hanieh, Müller-Nurasyid Martina, Couto Alves Alexessander, Strawbridge Rona J, Lataniotis Lazaros, An Hashim Nikman, Besse Céline, Boland Anne, Braund Peter S, Connell John M, Dominiczak Anna, Farmaki Aliki-Eleni, Franks Stephen, Grallert Harald, Jansson Jan-Håkan, Karaleftheri Maria, Keinänen-Kiukaanniemi Sirkka, Matchan Angela, Pasko Dorota, Peters Annette, Poulter Neil, Rayner Nigel W, Renström Frida, Rolandsson Olov, Sabater-Lleal Maria, Sennblad Bengt, Sever Peter, Shields Denis, Silveira Angela, Stanton Alice V, Strauch Konstantin, Tomaszewski Maciej, Tsafantakis Emmanouil, Waldenberger Melanie, Blakemore Alexandra I F, Dedoussis George, Escher Stefan A, Kooner Jaspal S, McCarthy Mark I, Palmer Colin N A, Hamsten Anders, Caulfield Mark J, Frayling Timothy M, Tobin Martin D, Jarvelin Marjo-Riitta, Zeggini Eleftheria, Gieger Christian, Chambers John C, Wareham Nick J, Munroe Patricia B, Franks Paul W, Samani Nilesh J, Deloukas Panos
Abstract excerpt
It has been hypothesized that low frequency (1-5% minor allele frequency (MAF)) and rare (<1% MAF) variants with large effect sizes may contribute to the missing heritability in complex traits. Here, we report an association analysis of lipid traits (total cholesterol, LDL-cholesterol, HDL-cholesterol triglycerides) in up to 27 312 individuals with a comprehensive set of low frequency coding variants (ExomeChip),...
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