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Article

Population-specific genetic variation in large sequencing data sets: why more data is still better.

European journal of human genetics : EJHG - 1 Oct 2017

van Rooij Jeroen G J, Jhamai Mila, Arp Pascal P, Nouwens Stephan C A, Verkerk Marijn, Hofman Albert, Ikram M Arfan, Verkerk Annemieke J, van Meurs Joyce B J, Rivadeneira Fernando, Uitterlinden André G, Kraaij Robert

Abstract excerpt

We have generated a next-generation whole-exome sequencing data set of 2628 participants of the population-based Rotterdam Study cohort, comprising 669 737 single-nucleotide variants and 24 019 short insertions and deletions. Because of broad and deep longitudinal phenotyping of the Rotterdam Study, this data set permits extensive interpretation of genetic variants on a range of clinically relevant outcomes, and...

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Identifiers

PMID: 28905877
DOI: 10.1038/ejhg.2017.110
PMCID: PMC5602011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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