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Identity-by-descent detection across 487,409 British samples reveals fine-scale population structure, evolutionary history, and trait associations

2020-04-21

Abstract excerpt

Detection of Identical-By-Descent (IBD) segments provides a fundamental measure of genetic relatedness and plays a key role in a wide range of genomic analyses. We developed a new method, called FastSMC, that enables accurate biobank-scale detection of IBD segments transmitted by common ancestors living up to several hundreds of generations in the past. FastSMC combines a fast heuristic search for IBD segments wit...

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Literature Corpus work: e011d530-6fdc-5041-a616-050f9c829cb7
DOI: 10.1101/2020.04.20.029819

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