Article
Inferring Identical-by-Descent Sharing of Sample Ancestors Promotes High-Resolution Relative Detection.
American journal of human genetics - 5 Jul 2018
Ramstetter Monica D, Shenoy Sushila A, Dyer Thomas D, Lehman Donna M, Curran Joanne E, Duggirala Ravindranath, Blangero John, Mezey Jason G, Williams Amy L
Abstract excerpt
As genetic datasets increase in size, the fraction of samples with one or more close relatives grows rapidly, resulting in sets of mutually related individuals. We present DRUID-deep relatedness utilizing identity by descent-a method that works by inferring the identical-by-descent (IBD) sharing profile of an ungenotyped ancestor of a set of close relatives. Using this IBD profile, DRUID infers relatedness...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
