Article
Hypermethylation of HpaII recognition sequences within the 5' coding region of the estrogen receptor gene is not associated with estrogen receptor negativity in primary breast tumours.
Anticancer research - 1 Jan 2000
Kay P H, Hähnel R, Gunn H, Harmon D, Song J
Abstract excerpt
Estrogen receptor negative tumours are unable to respond to antiestrogen therapy. The underlying molecular mechanisms of estrogen receptor negativity are poorly understood. Cytosine mechylation is one of the mechanisms of gene control and previous studies, particularly on breast tumour derived ce...
Topics
- Adenocarcinoma
- Breast Neoplasms
- DNA Methylation
- DNA, Neoplasm
- DNA-Cytosine Methylases
- Female
- Genotype
- Humans
- Polymerase Chain Reaction
- Receptors, Estrogen
- Substrate Specificity