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Article

Epigenetic DNA Hypermethylation of the HERP Gene Promoter Induces Down‐regulation of Its mRNA Expression in Patients With Alcohol Dependence

29 Mar 2006

Abstract excerpt

BACKGROUND: Elevated plasma homocysteine concentrations can influence genomic and gene-specific DNA methylation in peripheral blood cells. The aim of this study was to investigate in patients with alcohol dependence, who show chronically elevated homocysteine levels, whether DNA methylation pattern within the HERP (homocysteine-induced endoplasmic reticulum protein) promoter region and expression of HERP mRNA is...

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PMID: 16573575
DOI: 10.1111/j.1530-0277.2006.00068.x

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