Article
Quantitative detection of methylated ESR1 and 14-3-3-sigma gene promoters in serum as candidate biomarkers for diagnosis of breast cancer and evaluation of treatment efficacy.
Cancer biology & therapy - 1 Jun 2008
Martínez-Galán Joaquina, Torres Blanca, Del Moral Rosario, Muñoz-Gámez José Antonio, Martín-Oliva David, Villalobos Mercedes, Núñez María Isabel, Luna Juan de Dios, Oliver Francisco Javier, Ruiz de Almodóvar José Mariano
Abstract excerpt
The aim of the present study was to investigate the association between gene hypermethylation and main clinicopathological features of breast cancer, including diagnosis and treatment response. A sensitive SYBR green methylation-specific PCR technique was used to analyze the utility of circulating DNA with CpG island hypermethylation of ESR1, APC, RARB, 14-3-3-sigma and E-cad gene promoter regions as breast...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.