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Aberrant DNA methylation of the p16INK4a gene in plasma DNA of breast cancer patients

28 May 1999

Abstract excerpt

Hypermethylation of exon 1 of p16INK4a was examined in tumour and plasma DNA of a series of breast cancer patients. De novo methylation was observed in the tumours of eight patients (23%), and in plasma DNA in five (14%) of these eight patients. Our data show that de novo methylation of exon 1 of p16INK4a can be demonstrated in plasma DNA of breast cancer patients, a fact that provides additional evidence of the...

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PMID: 10376981
DOI: 10.1038/sj.bjc.6690495

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