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Article

Metabolic reprogramming of macrophages: glucose transporter 1 (GLUT1)-mediated glucose metabolism drives a proinflammatory phenotype.

The Journal of biological chemistry - 14 Mar 2014

Freemerman Alex J, Johnson Amy R, Sacks Gina N, Milner J Justin, Kirk Erin L, Troester Melissa A, Macintyre Andrew N, Goraksha-Hicks Pankuri, Rathmell Jeffery C, Makowski Liza

Abstract excerpt

Glucose is a critical component in the proinflammatory response of macrophages (MΦs). However, the contribution of glucose transporters (GLUTs) and the mechanisms regulating subsequent glucose metabolism in the inflammatory response are not well understood. Because MΦs contribute to obesity-induced inflammation, it is important to understand how substrate metabolism may alter inflammatory function. We report that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24492615
DOI: 10.1074/jbc.M113.522037
PMCID: PMC3953299

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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