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Article

Relationship between CD4 T cell turnover, cellular differentiation and HIV persistence during ART

19 Jan 2021

Abstract excerpt

The precise role of CD4 T cell turnover in maintaining HIV persistence during antiretroviral therapy (ART) has not yet been well characterized. In resting CD4 T cell subpopulations from 24 HIV-infected ART-suppressed and 6 HIV-uninfected individuals, we directly measured cellular turnover by heavy water labeling, HIV reservoir size by integrated HIV-DNA (intDNA) and cell-associated HIV-RNA (caRNA), and HIV...

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PMID: 33465157
DOI: 10.1371/journal.ppat.1009214

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