Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Proviral Turnover During Untreated HIV Infection Is Dynamic and Variable Between Hosts, Impacting Reservoir Composition on ART

19 Aug 2021

Abstract excerpt

Human immunodeficiency virus (HIV) can persist as an integrated provirus, in a transcriptionally repressed state, within infected cells. This small yet enduring pool of cellular reservoirs that harbor replication-competent HIV is the main barrier to cure. Entry of viral sequences into cellular reservoirs begins shortly after infection, and cells containing integrated proviral DNA are extremely stable once...

Topics

Join the communities discussing this publication.

HIV/AIDS drug development and treatment
HIV/AIDS Research and Interventions
HIV Research and Treatment

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 34489909
DOI: 10.3389/fmicb.2021.719153

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Proviral Turnover During Untreated HIV Infection Is Dynamic and Variable Between Hosts, Impacting Reservoir Composition on ARTPMID 34489909Read ↗

HIV Proviral Burden, Genetic Diversity, and Dynamics in Viremic Controllers Who Subsequently Initiated Suppressive Antiretroviral Therapy.Semantic proximity Read ↗

HIV reservoirs are dominated by genetically younger and clonally enriched provirusesSemantic proximity Read ↗

Genetic Diversity, Compartmentalization, and Age of HIV Proviruses Persisting in CD4+ T Cell Subsets during Long-Term Combination Antiretroviral Therapy.Semantic proximity Read ↗

The replication-competent HIV reservoir is a genetically restricted, younger subset of the overall pool of HIV proviruses persisting during therapy, which is highly genetically stable over timeSemantic proximity Read ↗

Establishment and stability of the latent HIV-1 DNA reservoir.Semantic proximity Read ↗

Reduced evolutionary rates in HIV-1 reveal extensive latency periods among replicating lineages.Semantic proximity Read ↗

HIV-1 variants are archived throughout infection and persist in the reservoir.Semantic proximity Read ↗

The latent reservoir of inducible, infectious HIV-1 does not decrease despite decades of antiretroviral therapySemantic proximity Read ↗

Extensive characterization of HIV-1 reservoirs reveals links to plasma viremia before and during analytical treatment interruptionSemantic proximity Read ↗

HIV-1 diversity in viral reservoirs obtained from circulating T-cell subsets during early ART and beyond.Semantic proximity Read ↗

Bayesian Phylogenetic Inference of HIV Latent Lineage Ages Using Serial SequencesSemantic proximity Read ↗

Rapid biphasic decay of intact and defective HIV DNA reservoir during acute treated HIV diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.