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Article

Kinetics of Human Immunodeficiency Virus Type 1 Decay following Entry into Resting CD4 <sup>+</sup> T Cells

29 Jan 2005

Abstract excerpt

In untreated human immunodeficiency virus type 1 (HIV-1) infection, most viral genomes in resting CD4(+) T cells are not integrated into host chromosomes. This unintegrated virus provides an inducible latent reservoir because cellular activation permits integration, virus gene expression, and virus production. It remains controversial whether HIV-1 is stable in this preintegration state. Here, we monitored the...

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PMID: 15681422
DOI: 10.1128/jvi.79.4.2199-2210.2005

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