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Article

The protease activity of the paracaspase MALT1 is controlled by monoubiquitination.

Nature immunology - 1 Apr 2013

Pelzer Christiane, Cabalzar Katrin, Wolf Annette, Gonzalez Montserrat, Lenz Georg, Thome Margot

Abstract excerpt

The protease activity of the paracaspase MALT1 is central to lymphocyte activation and lymphomagenesis, but how this activity is controlled remains unknown. Here we identify a monoubiquitination of MALT1 on Lys644 that activated the protease function of MALT1. Monoubiquitinated MALT1 had enhanced protease activity, whereas a ubiquitination-deficient MALT1 mutant with replacement of that lysine with arginine...

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Share to Caspases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23416615
DOI: 10.1038/ni.2540

Genes

MALT1

Variants

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