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Article

Redox properties of human hemoglobin in complex with fractionated dimeric and polymeric human haptoglobin.

Free radical biology & medicine - 1 Apr 2014

Mollan Todd L, Jia Yiping, Banerjee Sambuddha, Wu Gang, Kreulen R Timothy, Tsai Ah-Lim, Olson John S, Crumbliss Alvin L, Alayash Abdu I

Abstract excerpt

Haptoglobin (Hp) is an abundant and conserved plasma glycoprotein, which binds acellular adult hemoglobin (Hb) dimers with high affinity and facilitates their rapid clearance from circulation after hemolysis. Humans possess three main phenotypes of Hp, designated Hp 1-1, Hp 2-1, and Hp 2-2. These variants exhibit diverse structural configurations and have been reported to be functionally nonequivalent. We have...

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Identifiers

PMID: 24486321
DOI: 10.1016/j.freeradbiomed.2014.01.030
PMCID: PMC4104362

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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