Article
Haptoglobin: From hemoglobin scavenging to human health.
Molecular aspects of medicine - 1 Jun 2020
di Masi Alessandra, De Simone Giovanna, Ciaccio Chiara, D'Orso Silvia, Coletta Massimo, Ascenzi Paolo
Abstract excerpt
Haptoglobin (Hp) belongs to the family of acute-phase plasma proteins and represents the most important plasma detoxifier of hemoglobin (Hb). The basic Hp molecule is a tetrameric protein built by two α/β dimers. Each Hp α/β dimer is encoded by a single gene and is synthesized as a single polypeptide. Following post-translational protease-dependent cleavage of the Hp polypeptide, the α and β chains are linked by...
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