Article
Phenotype-specific recombinant haptoglobin polymers co-expressed with C1r-like protein as optimized hemoglobin-binding therapeutics.
BMC biotechnology - 15 Mar 2018
Schaer Christian A, Owczarek Catherine, Deuel Jeremy W, Schauer Stefan, Baek Jin Hyen, Yalamanoglu Ayla, Hardy Matthew P, Scotney Pierre D, Schmidt Peter M, Pelzing Matthias, Soupourmas Peter, Buehler Paul W, Schaer Dominik J
Abstract excerpt
BACKGROUND: Preclinical studies have evaluated haptoglobin (Hp) polymers from pooled human plasma as a therapeutic protein to attenuate toxic effects of cell-free hemoglobin (Hb). Proof of concept studies have demonstrated efficacy of Hp in hemolysis associated with transfusion and sickle cell anemia. However, phenotype-specific Hp products might be desirable to exploit phenotype specific activities of Hp 1-1...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.