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Human Hp1-1 and Hp2-2 Phenotype-Specific Haptoglobin Therapeutics Are Both Effective <i>In Vitro</i> and in Guinea Pigs to Attenuate Hemoglobin Toxicity

18 Feb 2013

Abstract excerpt

AIMS: Infusion of purified haptoglobin (Hp) functions as an effective hemoglobin (Hb) scavenging therapeutic in animal models of hemolysis to prevent cardiovascular and renal injury. Epidemiologic studies demonstrate the phenotype heterogeneity of human Hp proteins and suggest differing vascular protective potential imparted by the dimeric Hp1-1 and the polymeric Hp2-2. RESULTS: In vitro experiments and in vivo...

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Identifiers

PMID: 23418677
DOI: 10.1089/ars.2012.5089

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