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Hepatocellular carcinoma evades RB1-induced senescence by activating the FOXM1–FOXO1 axis

27 Jun 2022

Abstract excerpt

Hepatocellular carcinoma (HCC) is one of the deadliest cancers. The retinoblastoma protein (RB1), a regulator of cell proliferation, is functionally inactivated in HCC by CYCLIN D/E-mediated phosphorylation. However, the mechanism of RB1-inactivation is unclear because only small percentages of HCCs exhibit amplification of CYCLIN D/E or mutations in the CDK-inhibitory genes. We show that FOXM1, which is...

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PMID: 35761036
DOI: 10.1038/s41388-022-02394-8

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