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Article

A molecular analysis of quinolone-resistant Haemophilus influenzae: validation of the mutations in Quinolone Resistance-Determining Regions.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy - 1 Apr 2014

Shoji Hisashi, Shirakura Tetsuro, Fukuchi Kunihiko, Takuma Takahiro, Hanaki Hideaki, Tanaka Kazuo, Niki Yoshihito

Abstract excerpt

The mechanism of quinolone-resistance is considered to be amino acid mutations in the type II topoisomerase. We validated the genetic mechanisms of quinolone resistance in Haemophilus influenzae. We obtained 29 H. influenzae strains from a nationwide surveillance program in Japan (including 11 quinolone-resistant strains [moxifloxacin: MFLX or levofloxacin MIC ≥2 μg/ml]). We analyzed the sequences of the...

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Identifiers

PMID: 24480551
DOI: 10.1016/j.jiac.2013.12.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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