Article
Contribution of Type II Topoisomerase Mutations to Fluoroquinolone Resistance in Enterococcus faecium from Japanese Clinical Setting.
Microbial drug resistance (Larchmont, N.Y.) - 1 Jan 2000
Urushibara Noriko, Suzaki Keisuke, Kawaguchiya Mitsuyo, Aung Meiji Soe, Shinagawa Masaaki, Takahashi Satoshi, Kobayashi Nobumichi
Abstract excerpt
High-level fluoroquinolone resistance is conferred by the mutation of conserved serine and acidic amino acids in the quinolone resistance-determining region (QRDR) of the A subunits of the type II topoisomerases, DNA gyrase (GyrA) and topoisomerase IV (ParC). In Japan, fluoroquinolone-resistant E...
Topics
- Amino Acid Sequence
- Anti-Bacterial Agents
- Binding Sites
- DNA Gyrase
- DNA Topoisomerase IV
- Drug Resistance, Bacterial
- Enterococcus faecium
- Fluoroquinolones
- Gene Expression
- Gram-Positive Bacterial Infections
- Humans
- Japan
- Levofloxacin
- Microbial Sensitivity Tests