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Contribution of Type II Topoisomerase Mutations to Fluoroquinolone Resistance in Enterococcus faecium from Japanese Clinical Setting.

Microbial drug resistance (Larchmont, N.Y.) - 1 Jan 2000

Urushibara Noriko, Suzaki Keisuke, Kawaguchiya Mitsuyo, Aung Meiji Soe, Shinagawa Masaaki, Takahashi Satoshi, Kobayashi Nobumichi

Abstract excerpt

High-level fluoroquinolone resistance is conferred by the mutation of conserved serine and acidic amino acids in the quinolone resistance-determining region (QRDR) of the A subunits of the type II topoisomerases, DNA gyrase (GyrA) and topoisomerase IV (ParC). In Japan, fluoroquinolone-resistant Enterococcus faecium continues to emerge in clinical settings. We analyzed 131 Japanese E. faecium clinical isolates for...

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PMID: 28504916
DOI: 10.1089/mdr.2016.0328

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